abstract：:Age-related neurodegenerative diseases are characterized by selective neuron loss, glial activation, inflammation and abnormalities in oxidative metabolism. Thiamine deficiency (TD) is a model of neurodegeneration induced by impairment of oxidative metabolism. TD produces a time-dependent, selective neuronal death in ...

journal_title：Neurochemistry international

authors： Ke ZJ,Gibson GE

更新日期：2004-07-01 00:00:00

abstract：:Allosteric modulation of [3H]strychnine binding to glycine receptors (GlyRs) was examined in synaptosomal membranes of rat spinal cord. An allosteric model enabled us to determine the cooperativity factors of the allosteric agents with [3H]strychnine and glycine bindings (alpha and beta, respectively). We modified the...

journal_title：Neurochemistry international

authors： Bíró T,Maksay G

更新日期：2004-06-01 00:00:00

abstract：:Human neuroblastoma GOTO cell lines were established that stably express recombinant human lysosomal protective protein/cathepsin A (PPCA) cDNA by transfection. Intracellular cathepsin A (acid serine carboxypeptidase) activity increased four-fold compared with in those of the parent and mock-transfected cell lines. Th...

journal_title：Neurochemistry international

authors： Itoh K,Satoh Y,Kadota Y,Oheda Y,Kuwahara J,Shimmoto M,Sakuraba H

更新日期：2004-05-01 00:00:00

abstract：:In this study, the role of exogenous fatty acids in the regulation of proteolipid protein (PLP) gene expression was investigated using the following model culture system: C6 glioma cells expressing the green-fluorescent protein (eGFP) driven by different segments of PLP promoter. Eicosapentanoic acid (EPA; 20:5 n-3), ...

journal_title：Neurochemistry international

authors： Salvati S,Natali F,Attorri L,Raggi C,Di Biase A,Sanchez M

更新日期：2004-04-01 00:00:00

abstract：:The agonist, [3H](-)[S]-1-(2-amino-2-carboxyethyl)-5-fluoro-pyrimidine-2,4-dione ([3H](S)F-Willardiine) binding to functional alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors of resealed plasma membrane vesicles and nerve endings freshly isolated from the rat cerebral cortex displayed two bind...

journal_title：Neurochemistry international

authors： Kovács I,Simon A,Szárics E,Barabás P,Héja L,Nyikos L,Kardos J

更新日期：2004-03-01 00:00:00

abstract：:Platelet-activating factor (PAF), a biologically active lipid (1-O-alkyl-2-acetyl-sn-glycero-3-phosphoholine), is identified in different regions of brain, including hippocampus. Specific PAF-activated receptors (PAFRs) are expressed in corresponding brain areas. PAF has been proposed to be a retrograde messenger of l...

journal_title：Neurochemistry international

authors： Kondratskaya EL,Pankratov YV,Lalo UV,Chatterjee SS,Krishtal OA

更新日期：2004-02-01 00:00:00

abstract：:Rapid administration of large doses of ammonia leads to death of animals, which is largely prevented by pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonists. The present study focuses on a subunit(s) of NMDA receptor involved in ammonia-induced death by use of NMDA receptor GluRepsilon subunit-deficient ...

journal_title：Neurochemistry international

authors： Kitano T,Matsumura S,Seki T,Hikida T,Sakimura K,Nagano T,Mishina M,Nakanishi S,Ito S

更新日期：2004-01-01 00:00:00

abstract：:Recently, a new experimental model of epilepsy was introduced by the authors [Neurochem. Int. 40 (2002) 413]. This model combines pentylenetetrazole (PTZ)-kindling in senescence-accelerated mice P8 (SAMP8), a genetic model of aging. Since imbalance of glutamate and GABA is a major cause of seizures, the study of glial...

journal_title：Neurochemistry international

authors： Kondziella D,Hammer J,Sletvold O,Sonnewald U

更新日期：2003-12-01 00:00:00

abstract：:Glutamine has multiple physiological and pathophysiological roles in the brain. Because of their position at the interface between blood and brain, the cerebral capillaries and the choroid plexuses that form the blood-brain barriers (BBB) and blood-cerebrospinal fluid (CSF) barriers, have the potential to influence br...

journal_title：Neurochemistry international

authors： Xiang J,Ennis SR,Abdelkarim GE,Fujisawa M,Kawai N,Keep RF

更新日期：2003-09-01 00:00:00

abstract：:Malfunctioning of high-affinity glutamate transporters is believed to contribute to the accumulation of toxic concentrations of glutamate and, thus, trigger the cellular mechanisms of neurodegeneration. Emerging data point to the presence of excitotoxic component in Alzheimer's disease (AD) and aberrant expression of ...

journal_title：Neurochemistry international

authors： Rodriguez-Kern A,Gegelashvili M,Schousboe A,Zhang J,Sung L,Gegelashvili G

更新日期：2003-09-01 00:00:00

abstract：:The system of GABA transporters in neural cells constitutes an efficient mechanism for terminating inhibitory GABAergic neurotransmission. As such these transporter are important therapeutical targets in epilepsy and potentially other neurological diseases related to the GABA system. In this study a number of analogs ...

journal_title：Neurochemistry international

authors： Sarup A,Larsson OM,Bolvig T,Frølund B,Krogsgaard-Larsen P,Schousboe A

更新日期：2003-09-01 00:00:00

abstract：:Increased brain ammonia concentrations are a hallmark feature of several neurological disorders including congenital urea cycle disorders, Reye's syndrome and hepatic encephalopathy (HE) associated with liver failure. Over the last decade, increasing evidence suggests that hyperammonemia leads to alterations in the gl...

journal_title：Neurochemistry international

authors： Chan H,Butterworth RF

更新日期：2003-09-01 00:00:00

abstract：:Cholesterol, a molecule critical for cellular function, is found in particular high concentration in the brain and has been implicated to synaptic plasticity and neuronal regeneration. This study was undertaken to investigate the mechanism by which cholesterol shortage modulates glutamate (Glu)-induced excitotoxicity ...

journal_title：Neurochemistry international

authors： Chou YC,Lin SB,Tsai LH,Tsai HI,Lin CM

更新日期：2003-08-01 00:00:00

abstract：:Prenatal exposure to diazepam (DZ), a positive allosteric modulator of the gamma-aminobutyric acid(A) (GABA(A)) receptor complex, exerts profound effects that become more evident during puberty and in many cases are sex-specific, suggesting that such exposure interferes with the activity of steroid hormones. Apart fro...

journal_title：Neurochemistry international

authors： Cannizzaro C,D'Amico M,Altobelli D,Preziosi P,Martire M

更新日期：2003-07-01 00:00:00

abstract：:Pyrrolidinedithiocarbamate (PDTC) is a compound displaying antioxidant, pro-oxidant and metal chelator properties in different cell types. It has been described that PDTC may exert either anti-apoptotic or apoptotic activity. Moreover it is known that this agent regulates the activity of redox-sensitive transcription ...

journal_title：Neurochemistry international

authors： Porcile C,Stanzione S,Piccioli P,Bajetto A,Barbero S,Bisaglia M,Bonavia R,Florio T,Schettini G

更新日期：2003-07-01 00:00:00

abstract：:Activation of astrocytes occurs during many forms of CNS injury, but its importance for neuronal survival is poorly understood. When hippocampal cultures of neurons and astrocytes were treated from day 2-4 in vitro (DIV 2-4) with 1 microM cytosine arabinofuranoside (AraC), we observed a stellation of astrocytes, an in...

journal_title：Neurochemistry international

authors： Ahlemeyer B,Kölker S,Zhu Y,Hoffmann GF,Krieglstein J

更新日期：2003-06-01 00:00:00

abstract：:The results of the present study showed the presence of a high-affinity and saturable binding of [3H]-ketanserin to frontal and parietal brain membranes obtained postmortem from bipolar, depressed, schizophrenic patients and normal controls. The human brain samples (60 frontal cortex and 51 parietal cortex), were dona...

journal_title：Neurochemistry international

authors： Marazziti D,Giannaccini G,Giromella A,Betti L,Pesce D,Nardi I,Rossi A,Lucacchini A,Cassano GB

更新日期：2003-05-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of (3S)-7-chloro-3-[2-((1R)-1-carboxyethoxy)-4-aminomethylphenyl]aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[c,d]indole-2-carboxylic acid hydrochloride (SM-31900), an antagonist with high selectivity and affinity for the NMDA receptor glycine-binding site, on the ...

journal_title：Neurochemistry international

authors： Ohtani K,Tanaka H,Ohno Y

更新日期：2003-04-01 00:00:00

abstract：:The present experiments investigated the effect of a neurotoxin purified from the venom of the spider Phoneutria nigriventer. This toxic component, P. nigriventer toxin 3-6 (PnTx3-6), abolished Ca(2+)-dependent glutamate release with an IC(50) of 74.4nM but did not alter Ca(2+)-independent secretion of glutamate when ...

journal_title：Neurochemistry international

authors： Vieira LB,Kushmerick C,Reis HJ,Diniz CR,Cordeiro MN,Prado MA,Kalapothakis E,Romano-Silva MA,Gomez MV

更新日期：2003-03-01 00:00:00

abstract：:To characterise ketamine-induced sympathomimetic action, we examined the effects of ketamine on in vivo cardiac sympathetic nerve endings function. Using adult cats given anaesthesia with pentobarbital, dialysis probes were implanted in the left ventricular myocardium and dialysate noradrenaline (NA) concentrations we...

journal_title：Neurochemistry international

authors： Kitagawa H,Yamazaki T,Akiyama T,Mori H,Sunagawa K

更新日期：2003-02-01 00:00:00

abstract：:Chronic variate stress was seen to decrease the ingestion of sweet food when compared to control rats. Brain monoamines are known to be involved in the control of food intake, serotonin appears to be involved in the mechanisms of satiety, and dopamine in mediating appetite or approach behaviors triggered by incentive ...

journal_title：Neurochemistry international

authors： Gamaro GD,Manoli LP,Torres IL,Silveira R,Dalmaz C

更新日期：2003-01-01 00:00:00

abstract：:Protein kinase C (PKC) is involved in several cell events including proliferation, survival and differentiation. The aim of this work was to investigate the role of PKC activation on retinal cells proliferation. We demonstrated that PKC activation by phorbol 12-myristate 13-acetate (PMA), a tumor promoter phorbol este...

journal_title：Neurochemistry international

authors： dos Santos AA,Medina SV,Sholl-Franco A,de Araujo EG

更新日期：2003-01-01 00:00:00

abstract：:The amyloid precursor protein (APP) and presenilin-1 (PS-1) are not only of importance for the normal functioning of the various neurons, but also play central roles in the pathogenesis of Alzheimer's disease (AD). Through the use of immunohistochemical and Western blot techniques, the bidirectional axonal transport o...

journal_title：Neurochemistry international

authors： Papp H,Pakaski M,Kasa P

更新日期：2002-12-01 00:00:00

abstract：:Astrocytes play an important role in chemical signalling, acting as receptive as well as secretory elements. They can express receptors for essentially all classical neurotransmitter substances and for a large variety of peptides. Recent evidence indicates that astrocytes are involved in the information processing wit...

journal_title：Neurochemistry international

authors： Volknandt W

更新日期：2002-11-01 00:00:00

abstract：:Gap junctions are transcellular pathways that enable a dynamic metabolic coupling and a selective exchange of biological signaling mediators. Throughout the course of the brain development these intercellular channels are assembled into regionally and temporally defined patterns. The present review summarizes the poss...

journal_title：Neurochemistry international

authors： Fróes MM,Menezes JR

更新日期：2002-11-01 00:00:00

abstract：:There is substantial evidence that hyperammonemia is one of the main factors contributing to the neurological alterations found in hepatic encephalopathy. The mechanisms by which chronic moderate hyperammonemia affects brain function involves alterations in neurotransmission at different steps. This article reviews th...

journal_title：Neurochemistry international

authors： Corbalán R,Hernández-Viadel M,Llansola M,Montoliu C,Felipo V

更新日期：2002-08-01 00:00:00

abstract：:Human glutamate dehydrogenase (GDH) gene was fused with a gene fragment encoding the nine amino acid (RKKRRQRRR) protein transduction domain of human immunodeficiency virus TAT protein in bacterial expression vector to produce genetic in-frame TAT-GDH fusion protein. The TAT-GDH protein can enter PC12 cells efficientl...

journal_title：Neurochemistry international

authors： Yoon HY,Lee SH,Cho SW,Lee JE,Yoon CS,Park J,Kim TU,Choi SY

更新日期：2002-07-01 00:00:00

abstract：:We have found that the platelet activating factor antagonist (BN52021) is an effective blocker of the glycine (Gly) receptor-mediated responses in the hippocampal pyramidal neurons of rat. Using the whole-cell voltage clamp and concentration clamp recording techniques, we investigated the mechanism underlying the inhi...

journal_title：Neurochemistry international

authors： Kondratskaya EL,Lishko PV,Chatterjee SS,Krishtal OA

更新日期：2002-06-01 00:00:00

abstract：:The effects of the peroxovanadium complex potassium bisperoxo(1,10-phenanthroline)-oxovanadate (bpV[phen]) have been studied on dopamine (DA) exocytosis in PC12 cells. Bisperoxo(1,10-phenanthroline)-oxovanadate does not elicit dopamine secretion in PC12 cells. However, treatment of PC12 cells with 30 microM bpV[phen] ...

journal_title：Neurochemistry international

authors： Bieger S,Morinville A,Maysinger D

更新日期：2002-04-01 00:00:00

abstract：:Rat corticoencephalic cell cultures were investigated by high performance liquid chromatography for changes in the levels of adenosine 5'-triphosphate (ATP), guanosine 5'-triphosphate (GTP), uridine 5'-triphosphate (UTP), cytidine 5'-triphosphate (CTP), and the respective nucleoside diphosphates. Hypoxia was induced b...

journal_title：Neurochemistry international

authors： Reinhardt R,Manaenko A,Pissarek M,Wagner A,Illes P

更新日期：2002-04-01 00:00:00

abstract：:The aim of this study was to investigate the involvement of calmodulin in phospholipase D activation in SH-SY5Y cells. Cells prelabelled with [3H]-palmitic acid were incubated with calmodulin antagonists and/or other compounds. Phosphatidylethanol, a specific marker for phospholipase D activity, and phosphatidic acid ...

journal_title：Neurochemistry international

authors： del Carmen Boyano-Adánez M,Gustavsson L

更新日期：2002-03-01 00:00:00

abstract：:Cortical cells from embryonic mice (E17) showed a rapid cell-death under the serum-free condition. The addition of nefiracetam at 0.1-10 microM increased the survival activity, while aniracetam at the same concentrations did not. The cell death was characterized to be apoptotic, since dead cells showed nuclear condens...

journal_title：Neurochemistry international

authors： Fujita R,Takayama N,Ueda H

更新日期：2002-02-01 00:00:00

abstract：:Transglutaminase (TGase) activity is increased in affected regions of brains from patients with Huntington's disease (HD). TGase activity is particularly elevated in the nucleus compared with the cytoplasm from these brains. Gamma-glutaminyl-lysyl cross-links have been detected in nuclear inclusions in HD brain, indic...

journal_title：Neurochemistry international

authors： Karpuj MV,Becher MW,Steinman L

更新日期：2002-01-01 00:00:00

abstract：:Interleukin-1 beta (IL-1 beta) is a pro-inflammatory cytokine produced in the brain by endogenous microglial cells responding to injury. Levels of IL-1 beta are elevated in several neurodegenerative disorders, including Alzheimer's disease. IL-1 beta, which can act as a mitogen for astrocytes, also elicits the express...

journal_title：Neurochemistry international

authors： Chang JW,Young DA,Coleman PD,O'Banion MK

更新日期：2001-11-01 00:00:00

abstract：:Amyloid deposition within the brains of Alzheimer's Disease patients results in the activation of microglial cells and the induction of a local inflammatory response. The interaction of microglia or monocytes with beta-amyloid (A beta) fibrils elicits the activation a complex tyrosine kinase-based signal transduction ...

journal_title：Neurochemistry international

authors： Combs CK,Bates P,Karlo JC,Landreth GE

更新日期：2001-11-01 00:00:00

abstract：:An endogenous Na+, K+-ATPase inhibitor termed endobain E has been isolated from rat brain which shares several biological properties with ouabain. This cardiac glycoside possesses neurotoxic properties attributable to Na+, K+-ATPase inhibition, which leads to NMDA receptor activation, thus supporting the concept that ...

journal_title：Neurochemistry international

authors： Reinés A,Peña C,Rodríguez de Lores Arnaiz G

更新日期：2001-10-01 00:00:00

abstract：:We examined the vesicular accumulation of the excitatory amino-acid (EAA) neurotransmitters, L-glutamate and L-aspartate, together with the non-metabolisable EAA analogue D-aspartate. Synaptosomes derived from whole brain were incubated in various concentrations of [3H]-amino acids under conditions to facilitate vesic...

journal_title：Neurochemistry international

authors： Fleck MW,Barrionuevo G,Palmer AM

更新日期：2001-09-01 00:00:00

abstract：:Although the cerebral cortical dopamine D(1) receptor is considered to play a role in normal and abnormal brain function, little information is available on its characteristics in human brain. We compared dopamine-stimulated adenylyl cyclase (AC) activity in homogenates of cerebral cortex (frontal, temporal, parietal,...

journal_title：Neurochemistry international

authors： Tong J,Ross BM,Sherwin AL,Kish SJ

更新日期：2001-08-01 00:00:00

abstract：:In this study, the properties of ischemic condition-induced and veratridine-evoked [3H]noradrenaline ([3H]NA) release from rat spinal cord slices were compared. It was expected that ischemia mimicked by oxygen and glucose deprivation results in the impairment of Na+/K+ -ATPase with a consequent elevation of the intrac...

journal_title：Neurochemistry international

authors： Sumiya Y,Torigoe K,Gerevich Z,Köfalvi A,Vizi ES

更新日期：2001-07-01 00:00:00

abstract：:The precise function of activated microglia and their secretory products remains controversial. In order to assess the role of microglial secretion products, we established an in vitro model of an inflammatory reaction in the brain by co-culturing microglial and neuronal cell lines. Upon stimulation with interferon-ga...

journal_title：Neurochemistry international

authors： Hemmer K,Fransen L,Vanderstichele H,Vanmechelen E,Heuschling P

更新日期：2001-06-01 00:00:00